![]() This section contains information on the following topics: All instructions for setting up and execution are the same whether the object is viewed in its own window or in Phoenix view. Note: To view the object in its own window, select it in the Object Browser and double-click it or press ENTER. Right-click menu for a worksheet: Send To > NCA and Toolbox > NCA. Main menu: Insert > NCA and Toolbox > NCA. Right-click menu for a Workflow object: New > NCA and Toolbox > NCA. ![]() ![]() Use one of the following to add an NCA object to a Workflow: The drug effect model is for analysis of slope, height, areas, and moments in richly-sampled time-effect data. The plasma and urine models support rich datasets as well as sparsely-sampled studies such as toxicokinetic studies. Models 210–212 (urine concentrations) assume single-dose data, and the final parameters do not depend on the dose type. For steady-state data, the computation assumes equal dosing intervals (Tau) for each profile, and that the data are from a “final” dose given at steady-state. Models 200–202 can be used for either single-dose or steady-state data. Dose, time of last dose, dose interval (Tau) aĭose, length of infusion, time of last dose, dose interval (Tau) aĭose time, baseline effect, threshold (optional)ĪTau is required for steady-state data only.
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